Generally you should leave the default Windows drivers alone, because you can never anticipate when you might need a base driver. To restore a missing driver, you will need to run Host refresh or perform a repair reinstall.
To remove drivers, consider specific driver classes. For example, IEEE-3194 Firewire controllers or smart card readers if you don't have this hardware or your PC cannot support it (laptop with no capability).
If NTLite has a Compatibility mode protection for a driver, think twice before removing it. Some drivers are virtual devices (v*.sys), and unless they're directly related to Hyper-V support, should be avoided.